Grube married Mary Amanda Booher, daughter of John Bucher and Eliza Jane. (Mary Amanda Booher was born on 4 April 1847 in , Huntingdon, PA,1 2 died on 17 August 1874 in , Huntingdon, PA 1 and was buried in Mount Union: Mount Union Cemetery, Huntingdon, PA 1.)
1 Mount Union Cemetery, Mt. Union, Huntingdon County, PA (Online at: http://files.usgwarchives.net/pa/huntingdon/cemeteries/mtunioncemetery.txt).
2 1850 United States Census, Pennsylvania, Huntingdon County, Shirley Township, Series: M432 Roll: 784 Page: 178.